3-klor-5-hydroksybenzosyre CAS 53984-36-4

Produktbeskrivelse:

Produktnavn: 3-klor-5-hydroksybenzosyre CAS-NR: 53984-36-4

Synonymer:

5-klor-m-salisylsyre;3-klor-5-hydroksy BA;

Benzosyre, 3-klor-5-hydroksy-;

GPR81 Agonist, 3Cl-5OH-BA;

Kjemiske fysiske egenskaper:

Utseende: Hvitt til beige pulver

Analyse: Større enn eller lik 99,0 prosent

Tetthet: 1,536 g/cm3

Kokepunkt: 364.805 grader ved 760 mmHg

Smeltepunkt: 244.0 til 248.0 grader

Flammepunkt: 174.428 grader

Lagringstemp.: Forseglet i tørt, romtemperatur

Løselighet: DMSO: løselig 15 mg/ml (klar løsning)

Sikkerhetsinformasjon:

HS-kode: 2918290000

Advarsel: P261; P280; P305 pluss P351 pluss P338

Signalord: Fare

Symbol: GHS05, GHS07

Fareerklæring: H302; H315; H318; H335

5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects. GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.

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